Argan (Argania Spinosa)

ARGAN STEM CELLS

ARGAN STEM CELLS (ARGANIA SPINOSA)

One of the oldest tree species in the world, argan is indigenous to Morocco’s arid southwest region. Argan stem cells help tighten, tone, and enhance skin density. They nourish the complexion by replacing lost moisture while reducing the signs of aging.

AWARD FOR MOST INNOVATIVE INGREDIENT

How does it work?

STUDY #1: IMPROVING SKIN DENSITY IN THE UPPER DERMIS

The capacity of Argan Stem Cells to improve dermal tissue density was evaluated by visualizing the structure of the dermis using ultrasonography.

Changes in SLEB of 21 volunteers of average age 49 were monitored by analyzing ultrasonographic images taken from their forearms before and after treatment with either a 0.4% Argan stem cells cream or a corresponding placebo.

Results clearly show that Argan stem cells stimulates the regenerative capacity of the upper dermis tissue compared to the placebo. The SLEB is reduced due to an improved dermal tissue density:

• by 5.5% after 28 days of treatment

• by 13% after 56 days of treatment

S-364 / © Mibelle AG Biochemistry 2008

STUDY #2: MAINTENANCE OF HUMAN DERMAL STEM CELL CHARACTERISTICS

The newly established human dermal papilla cell culture was treated with 0.1% of the Argan stem cell extract. An untreated culture served as a control. Then, the effect on the dermal stem/progenitor cells was analyzed using the aforementioned parameters.

Compared to the control, the immunofluorescence images clearly show an intensified fluorescence signal (green) in spheres formed by dermal stem cells cultured with the Argan stem cell extract, indicating an enhanced production of the fluorescent-labeled Sox2 marker.

After several growth passages, cell cultures incubated with the Argan stem cell extract form almost 90% more spheres when seeded onto culture dishes compared to the control.

These results clearly demonstrate that Argan stem cells helps the dermal stem cells to maintain their stem cell characteristics.

S-330 / © Mibelle AG Biochemistry 2008

STUDY #3: ANTI-WRINKLE EFFECT ON CROW’S FEET

The anti-wrinkle effect was demonstrated in a half-face study with 21 healthy volunteers, average age 49. A cream containing 0.4% Argan stem cell or a placebo cream were applied twice daily, one to each side of the face including the crow’s feet. After 56 days, wrinkle depth was determined by the PRIMOS® technique.

Argan stem cells successfully reduced the wrinkle depth in crow’s feet area:

• by 19% after 28 days of treatment.

• by 26% after 56 days of treatment.